Early fetal growth: concepts and pitfalls

Early onset fetal growth restriction

Fetal growth restriction (FGR) diagnosed before 32 weeks is identified by fetal smallness associated with Doppler abnormalities and is associated with significant perinatal morbidity and mortality and maternal complications. Recent studies have provided new insights into pathophysiology, management options and postnatal outcomes of FGR. In this paper we review the available evidence regarding d...

Intrapartum fetal monitoring : overview , controversies and pitfalls

Growth and Development: Early Development and Fetal Programming

J. Anim. Sci. Vol. 88, E-Suppl. 2/J. Dairy Sci. Vol. 93, E-Suppl. 1/Poult. Sci. Vol. 89, E-Suppl. 1 635 Evaluation of the NCAPG I442M locus, a major gene for bovine prenatal growth, for effects on postnatal development compared to a disruptive mutation in the myostatin encoding gene GDF8. C. Kuehn*, P. Widmann, R. Pfuhl, and R. Weikard, Leibniz Institute for Farm Animal Biology (FBN), Dummersto...

Pitfalls of organismic concepts: "learned laziness"?

Early fetal hypoxia leads to growth restriction and myocardial thinning.

Hypoxia is necessary for fetal development; however, excess hypoxia is detrimental. Hypoxia has been extensively studied in the near-term fetus, but less is known about earlier fetal effects. The purpose of this study was to determine the window of vulnerability to severe hypoxia, what organ system(s) is most sensitive, and why hypoxic fetuses die. We induced hypoxia by reducing maternal-inspir...